Localization and level of proapoptotic protein regulators in a rat lung tissue during development of acute experimental bronchopneumonia

Apoptosis plays an important role in the development of acute inflammatory lung injury (AILI) and its consequences, which can be realized different cells with distinct intensity rate. The aim this study was to determine distribution expression apoptosis markers lungs rats AILI model endotracheal introduction capron thread LPS. Immunoblotting immunohistochemical studies were performed using monoclonal antibodies against Bax caspase-3 proteins. It shown that level increased significantly peak on 7th day. second 40 dimeric form noted 21st both pro-caspase-3 active also dramatically a maximum 5th day content observed These changes reflected activation key trigger periods during exudative hemorrhagic pneumonia subsequent fibrotic remodeling lungs. Keywords: AILI, apoptosis, Bax, caspase-3, lipopolysaccharide